BFA sends proteins back

BFA sends proteins back

O bserving a step backward brought Jon Yewdell a big step forward in understanding protein traffi cking pathways in the cell. As a newly minted assistant professor at the Wistar Institute, Yewdell was examining where in the cell the infl uenza A virus (IAV) hemagglutin (HA) trimerized. Using monoclonal antibodies (mAbs) specifi c for monomers or trimers, he had found by 1985 that monomers local...

BDNF sends mixed signals

A small toxin from a cyanobacterium pushes growth-promoting proteins such as the EGF receptor (EGFR) along an unusual path to destruction, report Shen et al. Several oncogenic proteins, including EGFR, p53, and cyclin-dependent kinases are collectively known as Hsp90 client proteins due to their reliance on the Hsp90 chaperone for maintaining their conformation and stability. Hsp90 inhibitors a...

Insulin sends SEC16A packing

After a meal, insulin lowers blood glucose levels by stimulating the sugar's uptake into muscle and fat cells via the glucose transporter GLUT4. Insulin promotes GLUT4's translocation to the cell surface, a process that goes awry in patients with type II diabetes and which depends, in part, on the small GTPase RAB10. Bruno and Brumfield et al. reveal that RAB10 works with SEC16A—a protein invol...

TCP - BFA : Bu er Fill

The main goal of a congestion avoidance algorithm is to maximize throughput and minimize delay (Jain & Ramakrishnan 1988). While TCP Reno achieves high throughput, it tends to consume all of the buuer space at the bottleneck router, causing large delays. In this paper we propose a simple scheme that modiies TCP Reno's congestion avoidance algorithm by throttling back the opening of the congesti...

Short title: BFA blocks translation